L-Theanine

The calming amino acid from green tea — promotes relaxation without drowsiness.

Also known as: Theanine • Gamma-glutamylethylamide • Suntheanine

other Names
Theanine, Gamma-glutamylethylamide, Suntheanine
primary Benefits
Calm focus, stress relief, sleep quality, caffeine synergy
common Dose
100–200 mg (or 200–400 mg for sleep)
best Form
Suntheanine (patented L-isomer)
timing
Any time; with caffeine for focus, evening for sleep
safety Rating
Very Safe — GRAS status, no known toxicity

Overview

L-Theanine is a unique amino acid found almost exclusively in tea leaves (Camellia sinensis), particularly green tea. It crosses the blood-brain barrier and promotes a state of calm, focused alertness by increasing alpha brain wave activity — the same brain wave pattern associated with meditation. Unlike most calming supplements, L-theanine doesn't cause drowsiness, making it ideal for daytime use. It's particularly popular when combined with caffeine, where it smooths out caffeine's jittery effects while preserving the focus and energy benefits.

Key Benefits

Calm Focus Without Drowsiness

L-Theanine increases alpha brain wave activity within 30–40 minutes of ingestion. Alpha waves are associated with a state of relaxed alertness — the same state achieved during meditation. This makes it unique among calming supplements.

Caffeine Synergy

The L-theanine + caffeine combination is one of the most well-studied nootropic stacks. L-theanine smooths out caffeine's jittery effects, reduces anxiety, and enhances the focus-promoting benefits. A typical ratio is 2:1 (200mg theanine to 100mg caffeine).

Stress & Anxiety Reduction

L-Theanine reduces cortisol and subjective stress without sedation. A study found that 200mg reduced stress response and heart rate during a challenging cognitive task.

Sleep Quality Improvement

While not a sedative, L-theanine at 200–400mg before bed improves sleep quality by promoting relaxation and reducing racing thoughts. It's particularly helpful for people whose sleep issues stem from an overactive mind.

Dosage & How to Take

Standard dose is 100–200mg for focus and stress relief, 200–400mg for sleep support.

PurposeDoseNotes
Calm focus100–200 mgCan be taken multiple times daily
With caffeine200 mg + 100 mg caffeine2:1 ratio is optimal
Stress relief200 mgAs needed; effects within 30 minutes
Sleep support200–400 mg30–60 minutes before bed

Best Time to Take

Effects felt within 30–40 minutes; lasts 4–6 hours

With or Without Food

Can be taken with or without food

Forms & Bioavailability

FormAbsorptionBest ForNotes
SuntheanineExcellentAll purposesPatented pure L-isomer; most studied form; enzymatically produced
Standard L-TheanineGoodBudget optionMay contain D-theanine isomer; still effective
Green tea extractGoodNatural source with other tea compoundsContains caffeine and catechins along with theanine

Side Effects & Safety

Common

  • Generally very well tolerated
  • Rare: mild headache

Rare

  • Dizziness at very high doses
  • GI discomfort

Contraindications

  • None known at standard doses
  • Caution with blood pressure medications (may lower BP slightly)

Interactions

CaffeinePositive

Synergistic — enhances focus while reducing jitteriness

Blood pressure medicationsLow

May slightly enhance blood pressure lowering

Stimulant medicationsLow

May modulate stimulant effects

Scientific Research

2008Asia Pacific Journal of Clinical Nutrition

L-Theanine and Alpha Waves

200mg L-theanine significantly increased alpha brain wave activity within 40 minutes

2010Nutritional Neuroscience

Theanine + Caffeine Combination

The combination improved attention, task switching, and reduced susceptibility to distraction

2016Journal of Functional Foods

L-Theanine and Stress

200mg reduced cortisol and heart rate response to acute stress

Food Sources

Green tea (25–50mg per cup)
Black tea (10–25mg per cup)
White tea (similar to green tea)
Some mushroom species (trace amounts)

Frequently Asked Questions

Medical Disclaimer

This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.