Research & Clinical Studies
Every recommendation on this site is backed by peer-reviewed research. Browse the clinical evidence behind our supplement profiles and guides.
Evidence Hierarchy
Showing 16 of 16 studies
Effects of creatine supplementation on cognitive function: a systematic review and meta-analysis
Avgerinos KI, Spyrou N, Bougioukas KI, et al. — Experimental Gerontology
A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root
Chandrasekhar K, Kapoor J, Anishetty S. — Indian Journal of Psychological Medicine
Oral collagen supplementation: a systematic review of dermatological applications
Choi FD, Sung CT, Juhasz ML, Mesinkovsk NA. — Journal of Drugs in Dermatology
Vitamin D supplementation for depressive symptoms: a systematic review and meta-analysis
Shaffer JA, Edmondson D, Wasson LT, et al. — Psychosomatic Medicine
Efficacy of omega-3 PUFAs in depression: a meta-analysis
Liao Y, Xie B, Zhang H, et al. — Translational Psychiatry
Magnesium intake and depression in adults
Tarleton EK, Littenberg B. — Journal of the American Board of Family Medicine
Improving the vitamin D status of vitamin D deficient adults is associated with improved mitochondrial oxidative function in skeletal muscle
Sinha A, Hollingsworth KG, Ball S, Cheetham T. — Journal of Clinical Endocrinology & Metabolism
Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice
Mori K, Inatomi S, Ouchi K, et al. — Biomedical Research
International Society of Sports Nutrition position stand: creatine supplementation and exercise
Kreider RB, Kalman DS, Antonio J, et al. — Journal of the International Society of Sports Nutrition
A double-blind, placebo-controlled, randomised study on the effects of a standardised Bacopa monnieri extract on cognitive performance
Stough C, Lloyd J, Clarke J, et al. — Psychopharmacology
Effects of zinc supplementation on the incidence of acne: a meta-analysis
Yee BE, Richards P, Sui JY, Marsch AF. — Journal of Clinical and Aesthetic Dermatology
Rhodiola rosea for physical and mental fatigue: a systematic review
Ishaque S, Shamseer L, Bukutu C, Vohra S. — BMC Complementary and Alternative Medicine
Curcumin for the treatment of major depression: a randomised, double-blind, placebo controlled study
Lopresti AL, Maes M, Maker GL, et al. — Journal of Affective Disorders
Probiotic supplementation reduces stress and anxiety: a meta-analysis
Liu RT, Walsh RFL, Sheehan AE. — Neuroscience & Biobehavioral Reviews
Effect of ashwagandha (Withania somnifera) root extract on testosterone and luteinizing hormone in men
Lopresti AL, Drummond PD, Smith SJ. — American Journal of Men's Health
Specific collagen peptides improve bone mineral density and bone markers in postmenopausal women
König D, Oesser S, Scharla S, et al. — Nutrients
Our Research Methodology
Every supplement recommendation on BestSellingSupplements.com is grounded in peer-reviewed clinical research. We prioritize meta-analyses and systematic reviews as the highest form of evidence, followed by randomized controlled trials (RCTs), cohort studies, and expert reviews.
We evaluate studies based on: sample size and statistical power, study design and methodology, conflict of interest disclosures, reproducibility across multiple trials, and clinical relevance of the outcomes measured.
Our evidence ratings reflect the overall body of research, not individual studies. A "Strong" rating means multiple high-quality trials with consistent results. "Moderate" means good evidence with some limitations. "Emerging" means promising early research that needs more confirmation.
This page is regularly updated as new research is published. Last updated: February 2026.